Major breast cancer contributor

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Metrics details. Environmental factors play an important role in breast carcinogenesis. Opportunities for prevention are limited, however, because most of the known or suspected risk factors are not targets for modification.

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A risk factor is anything that increases your chances of getting a disease, such as breast cancer. But having a risk factor, or even many, does not mean that you are sure to get the disease. Certain breast cancer risk factors are related to personal behaviors, such as diet and exercise.

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What causes breast cancer? Age 3. Lifestyle 5.

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Several risk factors for breast cancer have been well documented. However, for the majority of women presenting with breast cancer it is not possible to identify specific risk factors IARC, ; Lacey et al. A familial history of breast cancer increases the risk by a factor of two or three.

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Scientists have used artificial intelligence to recognise patterns in breast cancer -- and uncovered five new types of the disease each matched to different personalised treatments. Their study applied AI and machine learning to gene sequences and molecular data from breast tumours, to reveal crucial differences among cancers that had previously been lumped into one type. The new study, led by a team at The Institute of Cancer Research, London, found that two of the types were more likely to respond to immunotherapy than others, while one was more likely to relapse on tamoxifen.

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Genes are short segments of DNA deoxyribonucleic acid found in chromosomes. DNA contains the instructions for building proteins. And proteins control the structure and function of all the cells that make up your body.

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Each breast contains 15 to 20 lobes of glandular tissue, arranged like the petals of a daisy. The lobes are further divided into smaller lobules that produce milk for breast-feeding. Small tubes ducts conduct the milk to a reservoir that lies just beneath your nipple.

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Studies have shown that your risk for breast cancer is due to a combination of factors. The main factors that influence your risk include being a woman and getting older. Most breast cancers are found in women who are 50 years old or older.

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Targeted cancer therapies have significantly improved the outlook for many patients. But they have not proved successful in controlling the brain metastases of several types of cancer. Up to half of all patients treated with targeted therapies for a type of breast cancer that is driven by overexpression of the HER2 gene eventually develop brain metastases, which are inevitably fatal. He and his team have also identified a treatment strategy that could overcome this resistance.

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